Article
Parkinson's disease-associated genetic variation is linked to quantitative expression of inflammatory genes.
PloS one - 1 Jan 2017
Pierce Steven, Coetzee Gerhard A
Abstract excerpt
Genome-wide association studies (GWAS) have linked dozens of single nucleotide polymorphisms (SNPs) with Parkinson's disease (PD) risk. Ascertaining the functional and eventual causal mechanisms underlying these relationships has proven difficult. The majority of risk SNPs, and nearby SNPs in linkage disequilibrium (LD), are found in intergenic or intronic regions and confer risk through allele-dependent...
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