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Article

Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.

Blood - 17 May 2018

Neo Wen Hao, Booth Christopher A G, Azzoni Emanuele, Chi Lijun, Delgado-Olguín Paul, de Bruijn Marella F T R, Jacobsen Sten Eirik W, Mead Adam J

Abstract excerpt

Despite the well-established cell-intrinsic role of epigenetic factors in normal and malignant hematopoiesis, their cell-extrinsic role remains largely unexplored. Herein we investigated the hematopoietic impact of inactivating Ezh2, a key component of polycomb repressive complex 2 (PRC2), in the fetal liver (FL) vascular niche. Hematopoietic specific (Vav-iCre) Ezh2 inactivation enhanced FL hematopoietic stem...

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Identifiers

PMID: 29555646
DOI: 10.1182/blood-2017-10-811455
PMCID: PMC5960588

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Cell-extrinsic hematopoietic impact of Ezh2 inactivation in fetal liver endothelial cells.PMID 29555646Read ↗

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