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Article

Polycomb repressive complex 2 (PRC2) restricts hematopoietic stem cell activity.

PLoS biology - 15 Apr 2008

Majewski Ian J, Blewitt Marnie E, de Graaf Carolyn A, McManus Edward J, Bahlo Melanie, Hilton Adrienne A, Hyland Craig D, Smyth Gordon K, Corbin Jason E, Metcalf Donald, Alexander Warren S, Hilton Douglas J

Abstract excerpt

Polycomb group proteins are transcriptional repressors that play a central role in the establishment and maintenance of gene expression patterns during development. Using mice with an N-ethyl-N-nitrosourea (ENU)-induced mutation in Suppressor of Zeste 12 (Suz12), a core component of Polycomb Repressive Complex 2 (PRC2), we show here that loss of Suz12 function enhances hematopoietic stem cell (HSC) activity. In...

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Identifiers

PMID: 18416604
DOI: 10.1371/journal.pbio.0060093
PMCID: PMC2292752

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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