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Article

Early mammalian erythropoiesis requires the Dot1L methyltransferase.

Blood - 25 Nov 2010

Feng Yi, Yang Yanping, Ortega Manoela M, Copeland Jessica N, Zhang Mingcai, Jacob Jennifer B, Fields Timothy A, Vivian Jay L, Fields Patrick E

Abstract excerpt

Histone methylation is an important regulator of gene expression; its coordinated activity is critical in complex developmental processes such as hematopoiesis. Disruptor of telomere silencing 1-like (DOT1L) is a unique histone methyltransferase that specifically methylates histone H3 at lysine 79. We analyzed Dot1L-mutant mice to determine influence of this enzyme on embryonic hematopoiesis. Mutant mice...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20798234
DOI: 10.1182/blood-2010-03-276501
PMCID: PMC3321834

Genes

GATA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Early mammalian erythropoiesis requires the Dot1L methyltransferase.PMID 20798234Read ↗

The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure.Semantic proximity Read ↗

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The H3K4 methyltransferase Setd1b is essential for hematopoietic stem and progenitor cell homeostasis in miceSemantic proximity Read ↗

DOT1L as a therapeutic target for the treatment of DNMT3A-mutant acute myeloid leukemia.Semantic proximity Read ↗

Embryonic erythropoiesis and hemoglobin switching require transcriptional repressor ETO2 to modulate chromatin organizationSemantic proximity Read ↗

Histone methyltransferase Dot1L plays a role in postembryonic development in Xenopus tropicalis.Semantic proximity Read ↗

Early block to erythromegakaryocytic development conferred by loss of transcription factor GATA-1.Semantic proximity Read ↗

Mesenchyme-specific loss of Dot1L histone methyltransferase leads to skeletal dysplasia phenotype in mice.Semantic proximity Read ↗

Depletion of polycomb repressive complex 2 core component EED impairs fetal hematopoiesisSemantic proximity Read ↗

A mutation in the translation initiation codon of Gata-1 disrupts megakaryocyte maturation and causes thrombocytopenia.Semantic proximity Read ↗

The H3K4 methyltransferase KMT2D is an essential cofactor for GATA1 at erythroid gene enhancersSemantic proximity Read ↗

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