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Article

Mutations in Caenorhabditis elegans cytoplasmic dynein components reveal specificity of neuronal retrograde cargo.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 21 Apr 2004

Koushika Sandhya P, Schaefer Anneliese M, Vincent Rose, Willis John H, Bowerman Bruce, Nonet Michael L

Abstract excerpt

We describe Caenorhabditis elegans dynein complex mutants, which misaccumulate synaptic proteins at the ends of neuronal processes. Ultrastructural analysis revealed irregularly sized vesicles that likely represent accumulation of cargo. We propose that synaptobrevin, synaptotagmin, and UNC-104 are specific cargoes of the dynein complex. Many cargoes link to dynein via interactions between dynactin and...

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Identifiers

PMID: 15102906
DOI: 10.1523/JNEUROSCI.5039-03.2004
PMCID: PMC6729415

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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