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Article

Structure of Nascent Chromatin Is Essential for Hematopoietic Lineage Specification

1 Apr 2017

Abstract excerpt

HPCs possess a post-replicative chromatin globally devoid of the repressive histone mark H3K27me3. This H3K27-unmodified chromatin is required for recruitment of lineage-determining transcription factors (TFs) C/EBPα, PU.1, and GATA-1 to DNA just after DNA replication upon cytokine-induced myeloid or erythroid commitment. Blocking DNA replication or increasing H3K27me3 levels prevents recruitment of these TFs to...

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PMID: 28402853
DOI: 10.1016/j.celrep.2017.03.035

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