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Article

Notch and Hippo signaling converge on Strawberry Notch 1 (Sbno1) to synergistically activate Cdx2 during specification of the trophectoderm.

Scientific reports - 12 Apr 2017

Watanabe Yusuke, Miyasaka Kota Y, Kubo Atsushi, Kida Yasuyuki S, Nakagawa Osamu, Hirate Yoshikazu, Sasaki Hiroshi, Ogura Toshihiko

Abstract excerpt

The first binary cell fate decision occurs at the morula stage and gives rise to two distinct types of cells that constitute the trophectoderm (TE) and inner cell mass (ICM). The cell fate determinant, Cdx2, is induced in TE cells and plays an essential role in their differentiation and maintenance. Notch and Hippo signaling cascades are assumed to converge onto regulatory elements of Cdx2, however, the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28401892
DOI: 10.1038/srep46135
PMCID: PMC5389439

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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