Article
Characterization of the proneural gene regulatory network during mouse telencephalon development.
BMC biology - 31 Mar 2008
Gohlke Julia M, Armant Olivier, Parham Frederick M, Smith Marjolein V, Zimmer Celine, Castro Diogo S, Nguyen Laurent, Parker Joel S, Gradwohl Gerard, Portier Christopher J, Guillemot François
Abstract excerpt
BACKGROUND: The proneural proteins Mash1 and Ngn2 are key cell autonomous regulators of neurogenesis in the mammalian central nervous system, yet little is known about the molecular pathways regulated by these transcription factors. RESULTS: Here we identify the downstream effectors of proneural genes in the telencephalon using a genomic approach to analyze the transcriptome of mice that are either lacking or...
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