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Article

Genetic variants of PTPN2 are associated with lung cancer risk: a re-analysis of eight GWASs in the TRICL-ILCCO consortium.

Scientific reports - 11 Apr 2017

Feng Yun, Wang Yanru, Liu Hongliang, Liu Zhensheng, Mills Coleman, Han Younghun, Hung Rayjean J, Brhane Yonathan, McLaughlin John, Brennan Paul, Bickeboeller Heike, Rosenberger Albert, Houlston Richard S, Caporaso Neil E, Teresa Landi Maria, Brueske Irene, Risch Angela, Ye Yuanqing, Wu Xifeng, Christiani David C, Amos Christopher I, Wei Qingyi

Abstract excerpt

The T-cell protein tyrosine phosphatase (TCPTP) pathway consists of signaling events mediated by TCPTP. Mutations and genetic variants of some genes in the TCPTP pathway are associated with lung cancer risk and survival. In the present study, we first investigated associations of 5,162 single nucleotide polymorphisms (SNPs) in 43 genes of this TCPTP pathway with lung cancer risk by using summary data of six...

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Identifiers

PMID: 28400551
DOI: 10.1038/s41598-017-00850-0
PMCID: PMC5429754

Genes

PTPN2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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