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Article

Telomere maintenance genes SIRT1 and XRCC6 impact age-related decline in telomere length but only SIRT1 is associated with human longevity.

Biogerontology - 1 Apr 2012

Kim Sangkyu, Bi Xiuhua, Czarny-Ratajczak Malwina, Dai Jianliang, Welsh David A, Myers Leann, Welsch Michael A, Cherry Katie E, Arnold Jonathan, Poon Leonard W, Jazwinski S Michal

Abstract excerpt

Leukocyte telomere length is widely considered a biomarker of human age and in many studies indicative of health or disease. We have obtained quantitative estimates of telomere length from blood leukocytes in a population sample, confirming results of previous studies that telomere length significantly decreases with age. Telomere length was also positively associated with several measures of healthy aging, but...

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Identifiers

PMID: 21972126
DOI: 10.1007/s10522-011-9360-5
PMCID: PMC3272146

Genes

SIRT1
XRCC6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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