Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition.

PloS one - 1 Jan 2017

Chang Yao-Tsung, Shiu Jia-Hau, Huang Chun-Hao, Chen Yi-Chun, Chen Chiu-Yueh, Chang Yung-Sheng, Chuang Woei-Jer

Abstract excerpt

Rhodostomin (Rho) is a medium disintegrin containing a 48PRGDMP motif. We here showed that Rho proteins with P48A, M52W, and P53N mutations can selectively inhibit integrin αIIbβ3. To study the roles of the RGD loop and C-terminal region in disintegrins, we expressed Rho 48PRGDMP and 48ARGDWN mutants in Pichia pastoris containing 65P, 65PR, 65PRYH, 65PRNGLYG, and 65PRNPWNG C-terminal sequences. The effect of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blood Platelets
Share to Integrins
Share to Mass Spectrometry

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Oligopeptides

Share to Peptides

Share to Platelet Aggregation

Share to Protein Conformation

Share to Sequence Homology, Amino Acid

Source

Open in PubMed Open full text

Identifiers

PMID: 28399159
DOI: 10.1371/journal.pone.0175321
PMCID: PMC5388508

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition.PMID 28399159Read ↗

Modulation of integrin-binding selectivity by mutation within the RGD-loop of snake venom proteins: a novel drug development approach.Semantic proximity Read ↗

The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion.Semantic proximity Read ↗

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants.Semantic proximity Read ↗

Functional analysis of four single (RGDWL, RGDWM, RGDWP, RGDMN) and two double (RGDNM, RGDMP) mutants: The importance of methionine (M) in the functional potency of recombinant mojastin (r-Moj).Semantic proximity Read ↗

Consensus motif for integrin transmembrane helix association.Semantic proximity Read ↗

Function and antagonism of beta3 integrins in the development of cancer therapy.Semantic proximity Read ↗

RGD-containing trypsin with both platelet aggregation inhibitory activity and proteolytic activity.Semantic proximity Read ↗

Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins.Semantic proximity Read ↗

Functional Effect of the Mutations Similar to the Cleavage during Platelet Activation at Integrin β3 Cytoplasmic Tail when Expressed in Mouse Platelets.Semantic proximity Read ↗

Activation Mechanism of RhoA Caused by Constitutively Activating Mutations G14V and Q63L.Semantic proximity Read ↗

Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis.Semantic proximity Read ↗

Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.