Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins.

The Journal of biological chemistry - 31 Dec 1999

Wierzbicka-Patynowski I, Niewiarowski S, Marcinkiewicz C, Calvete J J, Marcinkiewicz M M, McLane M A

Abstract excerpt

There are key differences between the amino acid residues of the RGD loops and the C termini of echistatin, a potent antagonist of alpha(IIb)beta(3), alpha(v)beta(3) and alpha(5)beta(1), and eristostatin, a similar disintegrin selectively inhibiting alpha(IIb)beta(3). In order to identify echistatin motifs required for selective recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins, we expressed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to CHO Cells

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cricetinae

Share to Intercellular Signaling Peptides and Proteins

Share to Molecular Sequence Data

Share to Peptides

Share to Recombinant Proteins

Share to Sequence Homology, Amino Acid

Source

Identifiers

PMID: 10608843
DOI: 10.1074/jbc.274.53.37809

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural requirements of echistatin for the recognition of alpha(v)beta(3) and alpha(5)beta(1) integrins.PMID 10608843Read ↗

Tailoring echistatin to possess higher affinity for integrin alpha(IIb)beta(3).Semantic proximity Read ↗

The disintegrin echistatin stabilizes integrin alphaIIbbeta3's open conformation and promotes its oligomerization.Semantic proximity Read ↗

Coordinate Regulation of Estrogen-Mediated Fibronectin Matrix Assembly and Epidermal Growth Factor Receptor Transactivation by the G Protein-Coupled Receptor, GPR30Semantic proximity Read ↗

The mojastin mutant Moj-DM induces apoptosis of the human melanoma SK-Mel-28, but not the mutant Moj-NN nor the non-mutated recombinant Moj-WN.Semantic proximity Read ↗

Function and antagonism of beta3 integrins in the development of cancer therapy.Semantic proximity Read ↗

Modulation of integrin-binding selectivity by mutation within the RGD-loop of snake venom proteins: a novel drug development approach.Semantic proximity Read ↗

An activating mutation reveals a second binding mode of the integrin α2 I domain to the GFOGER motif in collagens.Semantic proximity Read ↗

Integrin αvβ3 binds a unique non-RGD site near the C-terminus of human tropoelastinSemantic proximity Read ↗

Effects of the RGD loop and C-terminus of rhodostomin on regulating integrin αIIbβ3 recognition.Semantic proximity Read ↗

Functional analysis of four single (RGDWL, RGDWM, RGDWP, RGDMN) and two double (RGDNM, RGDMP) mutants: The importance of methionine (M) in the functional potency of recombinant mojastin (r-Moj).Semantic proximity Read ↗

Discrete functional motifs reside within the cytoplasmic tail of alphaV integrin subunit.Semantic proximity Read ↗

Selective interaction of a conformationally-constrained Arg-Gly-Asp (RGD) motif with the integrin receptor alphavbeta3 expressed on human tumor cells.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.