Article
The effect of the single substitution of arginine within the RGD tripeptide motif of a modified neurotoxin dendroaspin on its activity of platelet aggregation and cell adhesion.
Cell communication & adhesion - 1 Jan 2000
Lu Xinjie, Davies Joanna, Lu Dong, Xia Min, Wattam Beth, Shang Dazhuang, Sun Yingqing, Scully Mike, Kakkar Vijay
Abstract excerpt
The Arg-Gly-Asp (RGD) tripeptide unit is a cell-cell and cell-extracellular matrix recognition sequence of some integrins that is found within several extracellular matrix glycoproteins and dendroaspin, a disintegrin-like venom protein isolated from the snake venom of the Dendroaspis jamsonii. In the present study, the RGD motif in dendroaspin was substituted by Lys-Gly-Asp (KGD), His-Gly-Asp (HGD), Gln-Gly-Asp...
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