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Article

Consensus motif for integrin transmembrane helix association.

Proceedings of the National Academy of Sciences of the United States of America - 12 Jan 2010

Berger Bryan W, Kulp Daniel W, Span Lisa M, DeGrado Jessica L, Billings Paul C, Senes Alessandro, Bennett Joel S, DeGrado William F

Abstract excerpt

Interactions between transmembrane (TM) helices play an important role in the regulation of diverse biological functions. For example, the TM helices of integrins are believed to interact heteromerically in the resting state; disruption of this interaction results in integrin activation and cellular adhesion. However, it has been difficult to demonstrate the specificity and affinity of the interaction between...

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Identifiers

PMID: 20080739
DOI: 10.1073/pnas.0910873107
PMCID: PMC2818961

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