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Article

Integrin α3β1 Binding to Fibronectin Is Dependent on the Ninth Type III Repeat.

The Journal of biological chemistry - 16 Oct 2015

Brown Ashley C, Dysart Marilyn M, Clarke Kimberly C, Stabenfeldt Sarah E, Barker Thomas H

Abstract excerpt

Fibronectin (Fn) is a promiscuous ligand for numerous cell adhesion receptors or integrins. The vast majority of Fn-integrin interactions are mediated through the Fn Arg-Gly-Asp (RGD) motif located within the tenth type III repeat. In the case of integrins αIIbβ3 and α5β1, the integrin binds RGD and the synergy site (PHSRN) located within the adjacent ninth type III repeat. Prior work has shown that these...

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Identifiers

PMID: 26318455
DOI: 10.1074/jbc.M115.656702
PMCID: PMC4646199

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