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Article

Inhibition of osteoporosis by the αvβ3 integrin antagonist of rhodostomin variants.

European journal of pharmacology - 5 Jun 2017

Lin Tzu-Hung, Yang Rong-Sen, Tu Huang-Ju, Liou Houng-Chi, Lin Yen-Ming, Chuang Woie-Jer, Fu Wen-Mei

Abstract excerpt

Integrins are heterodimeric cell surface receptors that mediate cell-cell and cell-matrix interaction. The vitronectin and osteopontin receptor αvβ3 integrin has increased expression levels and is implicated in the adhesion, activation, and migration of osteoclasts on the bone surface as well as osteoclast polarization. αvβ3 integrin plays an important role in osteoclast differentiation and resorption. In...

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Identifiers

PMID: 28315346
DOI: 10.1016/j.ejphar.2017.03.019

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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