RGD-containing trypsin with both platelet aggregation inhibitory activity and proteolytic activity.

doi:10.1080/15216549800203372

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Article

RGD-containing trypsin with both platelet aggregation inhibitory activity and proteolytic activity.

Biochemistry and molecular biology international - 1 Sept 1998

Nie X, Tang J G

Abstract excerpt

Arg-Gly-Asp (RGD) motif mediates cell adhesion as a major determinant in interactions of disintegrins with cell surface receptors. In order to obtain a mutant trypsin with both high affinity to integrins and retained proteolytic activity, RGDS and RGD were inserted into a rigid turn region and a...

Topics

Escherichia coli
Humans
Mutation
Oligopeptides
Platelet Aggregation
Platelet Aggregation Inhibitors
Protein Engineering
Trypsin

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