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Article

Key interactions in integrin ectodomain responsible for global conformational change detected by elastic network normal-mode analysis.

Biophysical journal - 15 Sept 2008

Matsumoto Atsushi, Kamata Tetsuji, Takagi Junichi, Iwasaki Kenji, Yura Kei

Abstract excerpt

Integrin, a membrane protein with a huge extracellular domain, participates in cell-cell and cell-extracellular-matrix interactions for metazoan. A group of integrins is known to perform a large-scale structural change when the protein is activated, but the activation mechanism and generality of the conformational change remain to be elucidated. We performed normal-mode analysis of the elastic network model on...

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Identifiers

PMID: 18515366
DOI: 10.1529/biophysj.108.131045
PMCID: PMC2527288

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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