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PDGF , Pericytes and the Pathogenesis of Idiopathic Basal Ganglia Calcification ( IBGC )

19 Jun 2014

Abstract excerpt

Platelet-derived growth factors (PDGFs) are important mitogens for various types of mesenchymal cells, and as such, they exert critical functions during organogenesis in mammalian embryonic and early postnatal development. Increased or ectopic PDGF activity may also cause or contribute to diseases such as cancer and tissue fibrosis. Until recently, no loss-of-function (LOF) mutations in PDGF or PDGF receptor...

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PMID: 24946076
DOI: 10.1111/bpa.12158

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