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Article

BinomiRare: A robust test of the association of a rare variant with a disease for pooled analysis and meta-analysis, with application to the HCHS/SOL.

Genetic epidemiology - 1 Jul 2017

Sofer Tamar

Abstract excerpt

Most regression-based tests of the association between a low-count variant and a binary outcome do not protect type 1 error, especially when tests are rejected based on a very low significance threshold. Noted exception is the Firth test. However, it was recently shown that in meta-analyzing multiple studies all asymptotic, regression-based tests, including the Firth, may not control type 1 error in some...

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Identifiers

PMID: 28393384
DOI: 10.1002/gepi.22044
PMCID: PMC5510891

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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