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Article

Quantifying posterior effect size distribution of susceptibility loci by common summary statistics.

Genetic epidemiology - 1 Jun 2020

Vsevolozhskaya Olga A, Zaykin Dmitri V

Abstract excerpt

Testing millions of single nucleotide polymorphisms (SNPs) in genetic association studies has become a standard routine for disease gene discovery. In light of recent re-evaluation of statistical practice, it has been suggested that p-values are unfit as summaries of statistical evidence. Despite this criticism, p-values contain information that can be utilized to address the concerns about their flaws. We...

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PMID: 32100375
DOI: 10.1002/gepi.22286
PMCID: PMC7502413

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