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Article

PASTRY: achieving balanced power for detecting risk and protective minor alleles in meta-analysis of association studies with overlapping subjects.

BMC bioinformatics - 12 Jan 2024

Kim Emma E, Jang Chloe Soohyun, Kim Hakin, Han Buhm

Abstract excerpt

BACKGROUND: Meta-analysis is a statistical method that combines the results of multiple studies to increase statistical power. When multiple studies participating in a meta-analysis utilize the same public dataset as controls, the summary statistics from these studies become correlated. To solve this challenge, Lin and Sullivan proposed a method to provide an optimal test statistic adjusted for the correlation....

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PMID: 38216869
DOI: 10.1186/s12859-023-05627-z
PMCID: PMC10790263

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