Article
Power evaluation of asymptotic tests for comparing two binomial proportions to detect direct and indirect association in large-scale studies.
Statistical methods in medical research - 1 Dec 2017
Emily Mathieu, Friguet Chloé
Abstract excerpt
Asymptotic tests are commonly used for comparing two binomial proportions when the sample size is sufficiently large. However, there is no consensus on the most powerful test. In this paper, we clarify this issue by comparing the power functions of three popular asymptotic tests: the Pearson's χ2 test, the likelihood-ratio test and the odds-ratio based test. Considering Taylor decompositions under local...
Topics
- Biostatistics
- Case-Control Studies
- Computer Simulation
- Gene Frequency
- Genome-Wide Association Study
- Humans
- Likelihood Functions
- Logistic Models
- Models, Statistical
- Molecular Epidemiology
- Odds Ratio
- Polymorphism, Single Nucleotide
- Sample Size