Article
Meta-Analysis of Genome-Wide Association Studies with Correlated Individuals: Application to the Hispanic Community Health Study/Study of Latinos (HCHS/SOL).
Genetic epidemiology - 1 Sept 2016
Sofer Tamar, Shaffer John R, Graff Mariaelisa, Qi Qibin, Stilp Adrienne M, Gogarten Stephanie M, North Kari E, Isasi Carmen R, Laurie Cathy C, Szpiro Adam A
Abstract excerpt
Investigators often meta-analyze multiple genome-wide association studies (GWASs) to increase the power to detect associations of single nucleotide polymorphisms (SNPs) with a trait. Meta-analysis is also performed within a single cohort that is stratified by, e.g., sex or ancestry group. Having correlated individuals among the strata may complicate meta-analyses, limit power, and inflate Type 1 error. For...
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