Article

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportion

2021-01-09

Abstract excerpt

Whole genome and exome sequencing studies have become increasingly available and are being used to identify rare genetic variants associated with health and disease outcomes. Investigators routinely use mixed models to account for genetic relatedness or other clustering variables (e.g. family or household) when testing genetic associations. However, no existing tests of the association of a rare variant associatio...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2bc78605-52ae-5846-9417-cf5a379b6399
DOI: 10.1101/2021.01.08.21249450

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

BinomiRare: A carriers-only test for association of rare genetic variants with a binary outcome for mixed models and any case-control proportionDOI 10.1101/2021.01.08.21249450Read

A flexible approach for the analysis of rare variants allowing for a mixture of effects on binary or quantitative traits.Semantic proximity Read

Rare variants association testing for a binary outcome when pooling individual level data from heterogeneous studiesSemantic proximity Read

A unified mixed-effects model for rare-variant association in sequencing studies.Semantic proximity Read

Control for Population Structure and Relatedness for Binary Traits in Genetic Association Studies via Logistic Mixed Models.Semantic proximity Read

Robust rare variant association testing for quantitative traits in samples with related individuals.Semantic proximity Read

Rare variants association testing for a binary outcome when pooling individual level data from heterogeneous studies.Semantic proximity Read

FastBiCmrMLM: a fast and powerful compressed variance component mixed logistic model for big genomic case-control genome-wide association study.Semantic proximity Read

An evaluation of approaches for rare variant association analyses of binary traits in related samples.Semantic proximity Read

Comparison of statistical tests for association between rare variants and binary traits.Semantic proximity Read

Estimation and partitioning of polygenic variation captured by common SNPs for Alzheimer's disease, multiple sclerosis and endometriosis.Semantic proximity Read

Increased power of mixed models facilitates association mapping of 10 loci for metabolic traits in an isolated population.Semantic proximity Read

Incorporation of Heterogeneity in a Case-Control Study Through a Mixture ModelSemantic proximity Read