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Article

ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.

The EMBO journal - 30 May 2012

Joseph Nimesh, Hutterer Andrea, Poser Ina, Mishima Masanori

Abstract excerpt

In cytokinesis, there is a lengthy interval between cleavage furrow ingression and abscission, during which the midbody microtubule bundle provides both structural support for a narrow intercellular bridge and a platform that orchestrates the biochemical preparations for abscission. It is currently unclear how the midbody structure is stably maintained during this period. Here, we report a novel role for the...

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Share to 14-3-3 Proteins
Share to ADP-Ribosylation Factor 6
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 22580824
DOI: 10.1038/emboj.2012.139
PMCID: PMC3365424

Genes

ARF6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

ARF6 GTPase protects the post-mitotic midbody from 14-3-3-mediated disintegration.PMID 22580824Read ↗

Structural basis for Arf6-MKLP1 complex formation on the Flemming body responsible for cytokinesis.Semantic proximity Read ↗

Clks 1, 2 and 4 prevent chromatin breakage by regulating the Aurora B-dependent abscission checkpoint.Semantic proximity Read ↗

Equatorial retention of the contractile actin ring by microtubules during cytokinesis.Semantic proximity Read ↗

Leukemia-associated RhoGEF (LARG) is a novel RhoGEF in cytokinesis and required for the proper completion of abscission.Semantic proximity Read ↗

Abscission accomplished by PtdIns(3)P.Semantic proximity Read ↗

Localization and activation of the ARF6 GTPase during cleavage furrow ingression and cytokinesis.Semantic proximity Read ↗

Regulation of midzone microtubule dynamics and abscission in human cells by CAMSAP2 and Kif2aSemantic proximity Read ↗

The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.Semantic proximity Read ↗

PtdIns(3)P controls cytokinesis through KIF13A-mediated recruitment of FYVE-CENT to the midbody.Semantic proximity Read ↗

Spermatocyte cytokinesis requires rapid membrane addition mediated by ARF6 on central spindle recycling endosomes.Semantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

The RAS GTPase RIT1 compromises mitotic fidelity through spindle assembly checkpoint suppressionSemantic proximity Read ↗

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