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Article

Cytokinesis: GAP gap.

Current biology : CB - 24 Feb 2009

Glotzer Michael

Abstract excerpt

The central spindle regulates cleavage furrow formation and cytokinesis and is composed of antiparallel microtubules bundled by microtubule-associated proteins and kinesin motors. One key protein in the central spindle is a Rho family GTPase-activating protein, CYK-4/MgcRacGAP, whose target is the subject of two new studies that arrive at divergent models.

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Identifiers

PMID: 19243691
DOI: 10.1016/j.cub.2008.12.028
PMCID: PMC8875700

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cytokinesis: GAP gap.PMID 19243691Read ↗

MgcRacGAP is involved in cytokinesis through associating with mitotic spindle and midbody.Semantic proximity Read ↗

CYK-4: A Rho family gtpase activating protein (GAP) required for central spindle formation and cytokinesis.Semantic proximity Read ↗

Inhibition of Rac by the GAP activity of centralspindlin is essential for cytokinesis.Semantic proximity Read ↗

Recruitment of cortexillin into the cleavage furrow is controlled by Rac1 and IQGAP-related proteins.Semantic proximity Read ↗

MgcRacGAP regulates cortical activity through RhoA during cytokinesis.Semantic proximity Read ↗

The MgcRacGAP SxIP motif tethers Centralspindlin to microtubule plus ends in Xenopus laevis.Semantic proximity Read ↗

An ECT2-centralspindlin complex regulates the localization and function of RhoA.Semantic proximity Read ↗

Distinct roles of Rho1, Cdc42, and Cyk3 in septum formation and abscission during yeast cytokinesis.Semantic proximity Read ↗

A complex of p190RhoGAP-A and anillin modulates RhoA-GTP and the cytokinetic furrow in human cells.Semantic proximity Read ↗

Cooperative assembly of CYK-4/MgcRacGAP and ZEN-4/MKLP1 to form the centralspindlin complex.Semantic proximity Read ↗

The putative exchange factor Gef3p interacts with Rho3p GTPase and the septin ring during cytokinesis in fission yeast.Semantic proximity Read ↗

Mechanisms for concentrating Rho1 during cytokinesis.Semantic proximity Read ↗

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