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Article

ABCB1 genetic polymorphisms affect opioid requirement by altering function of the intestinal P-glycoprotein.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Jul 2024

Qin Wangjun, Zhang Lei, Wang Xiaoxue, Liu Botao, Xu Liyuan, Liu Lihong, Fan Bifa

Abstract excerpt

The association between polymorphisms of the human ATP binding cassette subfamily B member 1 (ABCB1) gene and opioid response has attracted intense attention recently. As the ABCB1 gene encodes for the transporter P-glycoprotein in the brain and intestine involved in the pharmacokinetics of opioids, we investigated the effects of ABCB1 genetic polymorphisms on doses of opioids for pain relief and determined which...

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Identifiers

PMID: 38850645
DOI: 10.1016/j.biopha.2024.116897

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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