Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons.

Molecular cell - 6 Apr 2017

Lee Jongbo, Yoo Eunseok, Lee Hoyeon, Park Keunhee, Hur Jin-Hoe, Lim Chunghun

Abstract excerpt

ATAXIN-2 (ATX2) has been implicated in human neurodegenerative diseases, yet it remains elusive how ATX2 assembles specific protein complexes to execute its physiological roles. Here we employ the posttranscriptional co-activator function of Drosophila ATX2 to demonstrate that LSM12 and ME31B/DDX6 are two ATX2-associating factors crucial for sustaining circadian rhythms. LSM12 acts as a molecular adaptor for the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Behavior, Animal
Share to Circadian Clocks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Circadian Rhythm

Share to Circadian Rhythm Signaling Peptides and Proteins

Share to DEAD-box RNA Helicases

Share to Locomotion

Share to Multiprotein Complexes

Share to Period Circadian Proteins

Source

Identifiers

PMID: 28388438
DOI: 10.1016/j.molcel.2017.03.004

Genes

DDX6
LSM12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons.PMID 28388438Read ↗

ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila.Semantic proximity Read ↗

A role for Drosophila ATX2 in activation of PER translation and circadian behavior.Semantic proximity Read ↗

Ataxin-2: a powerful RNA-binding proteinSemantic proximity Read ↗

The Disease-Associated Proteins <i>Drosophila</i> Nab2 and Ataxin-2 Interact with Shared RNAs and Coregulate Neuronal MorphologySemantic proximity Read ↗

Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.Semantic proximity Read ↗

Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylationSemantic proximity Read ↗

Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formationSemantic proximity Read ↗

Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formationSemantic proximity Read ↗

An integrative approach to gain insights into the cellular function of human ataxin-2.Semantic proximity Read ↗

Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons.Semantic proximity Read ↗

The novel gene twenty-four defines a critical translational step in the Drosophila clock.Semantic proximity Read ↗

Biomedicine. Ataxin-1 regulators in the spotlight.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.