Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons.

Molecules and cells - 31 Oct 2020

Cha In Jun, Lee Davin, Park Sung Soon, Chung Chang Geon, Kim Seung Yeon, Jo Min Gu, Kim Seung Yeol, Lee Byung-Hoon, Lee Young-Sam, Lee Sung Bae

Abstract excerpt

Dendrites require precise and timely delivery of protein substrates to distal areas to ensure the correct morphology and function of neurons. Many of these protein substrates are supplied in the form of ribonucleoprotein (RNP) complex consisting of RNA-binding proteins (RBPs) and mRNAs, which are subsequently translated in distal dendritic areas. It remains elusive, however, whether key RBPs supply mRNA according...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dendrites
Share to Drosophila melanogaster

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Eukaryotic Initiation Factor-4E

Share to Fragile X Mental Retardation Protein

Share to Gene Expression Regulation

Share to Sensory Receptor Cells

Share to Up-Regulation

Source

Open in PubMed Open full text

Identifiers

PMID: 33115979
DOI: 10.14348/molcells.2020.0158
PMCID: PMC7604024

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Ataxin-2 Dysregulation Triggers a Compensatory Fragile X Mental Retardation Protein Decrease in Drosophila C4da Neurons.PMID 33115979Read ↗

A role for Drosophila ATX2 in activation of PER translation and circadian behavior.Semantic proximity Read ↗

ATAXIN-2 activates PERIOD translation to sustain circadian rhythms in Drosophila.Semantic proximity Read ↗

Ataxin-2: a powerful RNA-binding proteinSemantic proximity Read ↗

Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formationSemantic proximity Read ↗

Structured and disordered regions of Ataxin-2 contribute differently to the specificity and efficiency of mRNP granule formationSemantic proximity Read ↗

Direct binding of Ataxin-2 to distinct elements in 3' UTRs promotes mRNA stability and protein expression.Semantic proximity Read ↗

Localized molecular chaperone synthesis maintains neuronal dendrite proteostasisSemantic proximity Read ↗

LSM12 and ME31B/DDX6 Define Distinct Modes of Posttranscriptional Regulation by ATAXIN-2 Protein Complex in Drosophila Circadian Pacemaker Neurons.Semantic proximity Read ↗

Ataxin-2 polyglutamine expansions aberrantly sequester TDP-43 ribonucleoprotein condensates disrupting mRNA transport and local translation in neuronsSemantic proximity Read ↗

The spliceosome-associated protein Mfap1 binds to VCP in Drosophila.Semantic proximity Read ↗

Direct evidence that Ataxin-2 is a translational activator mediating cytoplasmic polyadenylationSemantic proximity Read ↗

Altered translational repression of an RNA-binding protein, Elav by AOA2-causative Senataxin mutation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.