Whole-Exome Sequencing of Vulvar Squamous Cell Carcinomas Reveals an Impaired Prognosis in Patients With TP53 Mutations and Concurrent CCND1 Gains.

doi:10.1016/j.modpat.2024.100574

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Article

Whole-Exome Sequencing of Vulvar Squamous Cell Carcinomas Reveals an Impaired Prognosis in Patients With TP53 Mutations and Concurrent CCND1 Gains.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2024

Ordi Oriol, Saco Adela, Peñuelas Núria, Blanco-Irazuegui Odei, Pino Marta Del, Carreras-Dieguez Núria, Marimon Lorena, Rodrigo-Calvo Maria Teresa, Morató Alba, Sisuashvili Lia, Bustamante Mariona, Cruells Adrià, Darecka Katarzyna, Vega Naiara, Alós Silvia, Trias Isabel, Fusté Pere, Parra Genis, Gut Marta, Munmany Meritxell, Torné Aureli, Jares Pedro, Rakislova Natalia

Abstract excerpt

Very little information is available on the mutational landscape of vulvar squamous cell carcinoma (VSCC), a disease that mainly affects older women. Studies focusing on the mutational patterns of the currently recognized etiopathogenic types of this tumor (human papillomavirus [HPV]-associated [HPV-A], HPV-independent [HPV-I] with TP53 mutation [HPV-I/TP53mut], and HPV-I with wild-type TP53 [HPV-I/TP53wt]) are...

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Identifiers

PMID: 39089654
DOI: 10.1016/j.modpat.2024.100574

Genes

TP53
CCND1
CDKN2A
FAT1
NFE2L2
PIK3CA
RNF213

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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