Article
Type-2 diabetes-associated variants with cross-trait relevance: Post-GWAs strategies for biological function interpretation.
Molecular genetics and metabolism - 1 May 2017
Frau Francesca, Crowther Daniel, Ruetten Hartmut, Allebrandt Karla V
Abstract excerpt
Genome-wide association studies (GWAs) for type 2 diabetes (T2D) have been successful in identifying many loci with robust association signals. Nevertheless, there is a clear need for post-GWAs strategies to understand mechanism of action and clinical relevance of these variants. The association of several comorbidities with T2D suggests a common etiology for these phenotypes and complicates the management of the...
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