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Article

Diverse type 2 diabetes genetic risk factors functionally converge in a phenotype-focused gene network.

PLoS computational biology - 1 Oct 2017

Sandor Cynthia, Beer Nicola L, Webber Caleb

Abstract excerpt

Type 2 Diabetes (T2D) constitutes a global health burden. Efforts to uncover predisposing genetic variation have been considerable, yet detailed knowledge of the underlying pathogenesis remains poor. Here, we constructed a T2D phenotypic-linkage network (T2D-PLN), by integrating diverse gene functional information that highlight genes, which when disrupted in mice, elicit similar T2D-relevant phenotypes....

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 29059180
DOI: 10.1371/journal.pcbi.1005816
PMCID: PMC5667928

Genes

PLN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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