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Article

Identification of novel type 2 diabetes candidate genes involved in the crosstalk between the mitochondrial and the insulin signaling systems.

PLoS genetics - 1 Jan 2012

Mercader Josep M, Puiggros Montserrat, Segrè Ayellet V, Planet Evarist, Sorianello Eleonora, Sebastian David, Rodriguez-Cuenca Sergio, Ribas Vicent, Bonàs-Guarch Sílvia, Draghici Sorin, Yang Chenjing, Mora Sílvia, Vidal-Puig Antoni, Dupuis Josée, Florez Jose C, Zorzano Antonio, Torrents David

Abstract excerpt

Type 2 Diabetes (T2D) is a highly prevalent chronic metabolic disease with strong co-morbidity with obesity and cardiovascular diseases. There is growing evidence supporting the notion that a crosstalk between mitochondria and the insulin signaling cascade could be involved in the etiology of T2D and insulin resistance. In this study we investigated the molecular basis of this crosstalk by using systems biology...

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Share to Diabetes Mellitus, Type 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23236286
DOI: 10.1371/journal.pgen.1003046
PMCID: PMC3516534

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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