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Article

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.

Annals of neurology - 1 Jun 2014

Li Jian-Guo, Chu Jin, Barrero Carlos, Merali Salim, Praticò Domenico

Abstract excerpt

OBJECTIVE: High level of homocysteine (Hcy) is a recognized risk factor for developing Alzheimer disease (AD). However, the mechanisms involved are unknown. Previously, it was shown that high Hcy increases brain β-amyloid (Aβ) levels in amyloid precursor protein transgenic mice, but no data are available on the effect that it may have on the other main pathologic features of AD such as tau. METHODS: 3xTg mice...

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Identifiers

PMID: 24644038
DOI: 10.1002/ana.24145
PMCID: PMC4362695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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