Article
One-carbon metabolism and Alzheimer's disease: is it all a methylation matter?
Neurobiology of aging - 1 Jul 2011
Fuso Andrea, Scarpa Sigfrido
Abstract excerpt
The sporadic form of Alzheimer disease, late onset Alzheimer's disease (LOAD), is a multifactorial disease; a strong link between nutritional and genetic factors with normal aging and dementia is supported by studies on nutrition, metabolism, and neurodegeneration. Specifically, the involvement of homocysteine (HCY) and its dietary determinants (vitamins B6, B12, and folate, besides methionine) in dementia has...
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