Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.

Journal of neurochemistry - 1 Jan 2011

McCampbell Alexander, Wessner Keith, Marlatt Michael W, Wolffe Carrie, Toolan Dawn, Podtelezhnikov Alexei, Yeh Suzie, Zhang Rena, Szczerba Peter, Tanis Keith Q, Majercak John, Ray William J, Savage Mary

Abstract excerpt

Elevated plasma homocysteine, a risk factor for Alzheimer's disease, could result from increased production from methionine or by inefficient clearance by folate- and B-vitamin-dependent pathways. Understanding the relative contributions of these processes to pathogenesis is important for therape...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Amyloid beta-Protein Precursor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Methionine

Share to Mice, Inbred C57BL

Share to Mice, Transgenic

Source

Identifiers

PMID: 21054384
DOI: 10.1111/j.1471-4159.2010.07087.x

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-21054384-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Induction of Alzheimer's-like changes in brain of mice expressing mutant APP fed excess methionine.PMID 21054384Read ↗

Elevated levels of brain homocysteine directly modulate the pathological phenotype of a mouse model of tauopathy.Semantic proximity Read ↗

Microglial-associated responses to comorbid amyloid pathology and hyperhomocysteinemia in an aged knock-in mouse model of Alzheimer’s diseaseSemantic proximity Read ↗

Five lipoxygenase hypomethylation mediates the homocysteine effect on Alzheimer's phenotype.Semantic proximity Read ↗

Homocysteine exacerbates β-amyloid pathology, tau pathology, and cognitive deficit in a mouse model of Alzheimer disease with plaques and tangles.Semantic proximity Read ↗

Hyperhomocysteinemic Alzheimer's mouse model of amyloidosis shows increased brain amyloid beta peptide levels.Semantic proximity Read ↗

Homocysteine modulates 5-lipoxygenase expression level via DNA methylationSemantic proximity Read ↗

Methylenetetrahydrofolate Reductase Deficiency Deregulates Regional Brain Amyloid-β Protein Precursor Expression and Phosphorylation Levels.Semantic proximity Read ↗

Maternal choline supplementation ameliorates Alzheimer’s disease pathology by reducing brain homocysteine levels across multiple generationsSemantic proximity Read ↗

Mice deficient in methylenetetrahydrofolate reductase exhibit hyperhomocysteinemia and decreased methylation capacity, with neuropathology and aortic lipid deposition.Semantic proximity Read ↗

Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse.Semantic proximity Read ↗

Mouse models of cystathionine beta-synthase deficiency reveal significant threshold effects of hyperhomocysteinemia.Semantic proximity Read ↗

Hyperhomocysteinemic mice show cognitive impairment without features of Alzheimer's disease phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.