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Article

Complex interactions between genes controlling trafficking in primary cilia.

Nature genetics - 1 Jun 2011

Ocbina Polloneal Jymmiel R, Eggenschwiler Jonathan T, Moskowitz Ivan, Anderson Kathryn V

Abstract excerpt

Cilia-associated human genetic disorders are striking in the diversity of their abnormalities and their complex inheritance. Inactivation of the retrograde ciliary motor by mutations in DYNC2H1 causes skeletal dysplasias that have strongly variable expressivity. Here we define previously unknown genetic relationships between Dync2h1 and other genes required for ciliary trafficking. Mutations in mouse Dync2h1...

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Identifiers

PMID: 21552265
DOI: 10.1038/ng.832
PMCID: PMC3132150

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Complex interactions between genes controlling trafficking in primary cilia.PMID 21552265Read ↗

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