Article

WDR11-mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome

2017-10-10

Abstract excerpt

WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11’s role in development is poorly understood. Here we report that WDR11 modulates the Hedgehog (Hh) signalling pathway and is essential for ciliogenesis. Disruption of WDR11 expression in mouse and zebrafish results in...

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Literature Corpus work: 9dd144f0-8201-5314-b8ec-b357d68ee07e
DOI: 10.1101/200154

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