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Maximizing Anticancer Response with MPS1 and CENPE Inhibition Alongside Apoptosis Induction

29 Dec 2023

Abstract excerpt

Antimitotic compounds, targeting key spindle assembly checkpoint (SAC) components (e.g., MPS1, Aurora kinase B, PLK1, KLP1, CENPE), are potential alternatives to microtubule-targeting antimitotic agents (e.g., paclitaxel) to circumvent resistance and side effects associated with their use. They can be classified into mitotic blockers, causing SAC-induced mitotic arrest, or mitotic drivers, pushing cells through...

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PMID: 38258067
DOI: 10.3390/pharmaceutics16010056

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