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Article

The adenosine generating enzymes CD39/CD73 control microglial processes ramification in the mouse brain.

PloS one - 1 Jan 2017

Matyash Marina, Zabiegalov Oleksandr, Wendt Stefan, Matyash Vitali, Kettenmann Helmut

Abstract excerpt

Microglial cells invade the brain as amoeboid precursors and acquire a highly ramified morphology in the postnatal brain. Microglia express all essential purinergic elements such as receptors, nucleoside transporters and ecto-enzymes, including CD39 (NTPDase1) and CD73 (5'-nucleotidase), which sequentially degrade extracellular ATP to adenosine. Here, we show that constitutive deletion of CD39 and CD73 or both...

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Identifiers

PMID: 28376099
DOI: 10.1371/journal.pone.0175012
PMCID: PMC5380357

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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