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Neurofibromatosis 1 - Mutant microglia exhibit sexually-dimorphic cyclic AMP-dependent purinergic defects.

Neurobiology of disease - 1 Oct 2020

Elmadany Nirmeen, Logiacco Francesca, Buonfiglioli Alice, Haage Verena C, Wright-Jin Elizabeth C, Schattenberg Alexander, Papawassiliou Roxane M, Kettenmann Helmut, Semtner Marcus, Gutmann David H

Abstract excerpt

As critical regulators of brain homeostasis, microglia are influenced by numerous factors, including sex and genetic mutations. To study the impact of these factors on microglia biology, we employed genetically engineered mice that model Neurofibromatosis type 1 (NF1), a disorder characterized by clinically relevant sexually dimorphic differences. While microglia phagocytic activity was reduced in both male and...

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PMID: 32736084
DOI: 10.1016/j.nbd.2020.105030

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