CD73 Controls Ocular Adenosine Levels and Protects Retina from Light-Induced Phototoxicity

Abstract excerpt

<title>Abstract</title> <p>Ocular ATP and adenosine have emerged as important signalling molecules involved in vascular remodeling, retinal functioning and neurovascular coupling in the mammalian eye. However, little is known about the regulatory mechanisms of purinergic signaling in the eye. Here, we used three-dimensional multiplexed imaging in combination with <italic>in situ</italic> enzyme histochemistry, fl...

Topics

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• Adenosine and Purinergic Signaling
• Adenosine Diphosphate
• Choristoma
• Eye
• Neuroinflammation and Neurodegeneration Mechanisms
• Neurological Complications and Syndromes
• Paired Box Transcription Factors
• Retinopathy of Prematurity Studies

Identifiers and source

Literature Corpus work

77b92c53-e291-5845-91e3-1b86c48b35d4

DOI

10.21203/rs.3.rs-743701/v1