Article
ATP and adenosine induce ramification of microglia in vitro.
Journal of neuroimmunology - 2 Apr 2001
Wollmer M A, Lucius R, Wilms H, Held-Feindt J, Sievers J, Mentlein R
Abstract excerpt
Microglial cells in the healthy adult brain possess a characteristic ramified morphology with multiple branched processes, small somata and down-regulated inflammatory properties. In contrast, microglial cells isolated from new-born rat brain inevitably show a non-ramified amoeboid phenotype, which is observed in vivo after pathologic activation or during development. To identify factors that control microglial...
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