Article

Nuclear Cx43 restrains microglial neurotoxicity during brain development

2026-07-03

Abstract excerpt

<h4>ABSTRACT</h4> Microglia are essential for sculpting the developing brain, yet the molecular mechanisms that select beneficial overreactive phagocytosis remain incompletely understood. Connexin 43 (Cx43, encoded by GJA1 in humans) is best known as a gap junction and hemichannel protein, although its non-canonical, channel-independent functions are increasingly recognized. We found that Cx43 is highly expresse...

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Literature Corpus work: f610ca60-b453-5ff9-9f67-5df84720588c
DOI: 10.64898/2026.06.29.735292

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