Spatiotemporal dynamics of CD73 in mouse retina under physiological conditions

Abstract excerpt

Adenosine is essential to energy metabolism and neuromodulation in the central nervous system. The retina is a highly energy-demanding neural tissue, and dysregulation of adenosine signaling causes retinal diseases. However, the dynamics of ecto-5’-nucleotidase (CD73), a key enzyme for extracellular adenosine generation, remain elusive. Here, we investigate its spatiotemporal profile from development to adulthood...

Topics

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• 5'-Nucleotidase
• Adenosine
• Adenosine and Purinergic Signaling
• Apyrase
• Brain Injuries
• Chemotaxis
• Neuroinflammation and Neurodegeneration Mechanisms
• Neurological Complications and Syndromes

Identifiers and source

Literature Corpus work

13af8ebf-bd1f-549e-bc05-92c40575f5e3

DOI

10.1101/2025.05.25.655881