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Article

Senescence Connects Autophagy Deficiency to Inflammation and Tumor Progression in the Liver

1 Jan 2022

Abstract excerpt

Background & Aims Cellular senescence frequently is present in injured livers. The induction mechanism and the pathologic role are not always clear. We aimed to understand the dynamics of senescence induction and progression, and the mechanism responsible for the pathology using a mouse model that disables the essential process of autophagy. Methods Mice deficient in key autophagy genes Atg7 or Atg5 in the liver...

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Share to Autophagy in Disease and Therapy
Share to Telomeres, Telomerase, and Senescence

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35398596
DOI: 10.1016/j.jcmgh.2022.04.003

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