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Article

Inhibition of autophagy alleviates the senescent state of rat mesenchymal stem cells during long-term culture

10 Oct 2014

Abstract excerpt

Following a limited number of cell divisions, mesenchymal stem cells (MSCs) undergo senescence, and these senescent cells maintain metabolic modification and remain viable for long periods. Autophagy, an intracellular bulk degradation process, provides a survival effect for cells under stress. In this study, the effect of autophagy on senescent MSCs was analyzed. Following serial passaging, rat MSCs underwent...

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PMID: 25310478
DOI: 10.3892/mmr.2014.2624

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