Article
MTOR regulates the pro-tumorigenic senescence-associated secretory phenotype by promoting IL1A translation.
Nature cell biology - 1 Aug 2015
Laberge Remi-Martin, Sun Yu, Orjalo Arturo V, Patil Christopher K, Freund Adam, Zhou Lili, Curran Samuel C, Davalos Albert R, Wilson-Edell Kathleen A, Liu Su, Limbad Chandani, Demaria Marco, Li Patrick, Hubbard Gene B, Ikeno Yuji, Javors Martin, Desprez Pierre-Yves, Benz Christopher C, Kapahi Pankaj, Nelson Peter S, Campisi Judith
Abstract excerpt
The TOR (target of rapamycin) kinase limits longevity by poorly understood mechanisms. Rapamycin suppresses the mammalian TORC1 complex, which regulates translation, and extends lifespan in diverse species, including mice. We show that rapamycin selectively blunts the pro-inflammatory phenotype of senescent cells. Cellular senescence suppresses cancer by preventing cell proliferation. However, as senescent cells...
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