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Epigallocatechin Gallate Effectively Affects Senescence and Anti-SASP via SIRT3 in 3T3-L1 Preadipocytes in Comparison with Other Bioactive Substances.

Oxidative medicine and cellular longevity - 1 Jan 2020

Lilja Stephanie, Oldenburg Julia, Pointner Angelika, Dewald Laura, Lerch Mariam, Hippe Berit, Switzeny Olivier, Haslberger Alexander

Abstract excerpt

AIM: We investigated different bioactive compounds including epigallocatechin gallate (EGCG), anthocyanidin, resveratrol, phloretin, spermidine, butyrate, and β-hydroxybutyrate with regard to their effect on SIRT3 via NRF2 and modulation of the proinflammatory senescence-associated secretory phenotype (SASP) in senescence induced 3T3-L1 preadipocytes. METHODS: For induction of senescence, 3T3-L1 preadipocytes...

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3T3-L1 Cells
Anthocyanins
Bromodeoxyuridine
Catechin
NF-E2-Related Factor 2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 33149809
DOI: 10.1155/2020/4793125
PMCID: PMC7603628

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